What World Solve is
World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.
For builders
Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.
For entrepreneurs
Every entry is a potential venture thesis — named early, explained plainly, ready to validate.
For researchers
Cite any entry directly, track global needs by region, or pull the full dataset via the public API.
1355 total logged
1355 still open
0 marked solved
7 registered profiles
We don't fully understand why some people age much slower than others.
open
Global / Unspecified, Global
Some people reach old age with sharp minds and healthy bodies, while others decline much earlier, and genetics only explains part of it. Understanding this gap could extend healthy years of life for far more people.
Citation ID: WS00065
Title: We don't fully understand why some people age much slower than others.
URL: https://worldsolve.org/index.php?api=problem&id=65
We haven't solved chronic pain well enough to treat it without risking addiction.
open
Global / Unspecified, Global
Millions of people with chronic pain are stuck choosing between inadequate relief or medications that carry serious addiction risk. A safer, equally effective alternative remains one of medicine's most requested breakthroughs.
Citation ID: WS00064
Title: We haven't solved chronic pain well enough to treat it without risking addiction.
URL: https://worldsolve.org/index.php?api=problem&id=64
We can't stop antibiotic-resistant bacteria from spreading faster than we develop new antibiotics.
open
Global / Unspecified, Global
Bacteria are evolving resistance faster than pharmaceutical companies are creating new antibiotics to fight them. Left unresolved, common infections could become deadly again within a few decades.
Citation ID: WS00063
Title: We can't stop antibiotic-resistant bacteria from spreading faster than we develop new antibiotics.
URL: https://worldsolve.org/index.php?api=problem&id=63
We don't have affordable cancer screening that catches every type early enough to treat well.
open
Global / Unspecified, Global
Some cancers are caught early and treated successfully, while others are found too late simply because no cheap, accurate screening exists for them. Broader early detection could save far more lives than treatment breakthroughs alone.
Citation ID: WS00062
Title: We don't have affordable cancer screening that catches every type early enough to treat well.
URL: https://worldsolve.org/index.php?api=problem&id=62
We haven't found a cure for the common cold despite decades of trying.
open
Global / Unspecified, Global
Hundreds of different viruses cause cold symptoms, making a single cure extremely difficult to develop. It remains one of medicine's most familiar yet unsolved problems.
Citation ID: WS00061
Title: We haven't found a cure for the common cold despite decades of trying.
URL: https://worldsolve.org/index.php?api=problem&id=61
We can't grow replacement organs that a patient's body won't reject.
open
Global / Unspecified, Global
Organ transplants still require lifelong drugs to stop the body from attacking the new organ, and many patients never get a match at all. Lab-grown organs from a patient's own cells could eliminate both problems.
Citation ID: WS00060
Title: We can't grow replacement organs that a patient's body won't reject.
URL: https://worldsolve.org/index.php?api=problem&id=60
We don't have a universal vaccine that protects against all strains of the flu.
open
Global / Unspecified, Global
The flu virus mutates constantly, forcing a new vaccine guess every year that sometimes misses the mark. A universal flu vaccine could end this annual guessing game and prevent thousands of deaths.
Citation ID: WS00059
Title: We don't have a universal vaccine that protects against all strains of the flu.
URL: https://worldsolve.org/index.php?api=problem&id=59
We can't cure most autoimmune diseases, only manage their symptoms.
open
Global / Unspecified, Global
Conditions like lupus, rheumatoid arthritis, and multiple sclerosis occur when the body attacks itself, and current treatments mostly suppress symptoms rather than fix the root cause. Millions live with lifelong management instead of a real cure.
Citation ID: WS00058
Title: We can't cure most autoimmune diseases, only manage their symptoms.
URL: https://worldsolve.org/index.php?api=problem&id=58