World Solve — A living repository of problems worth solving.

What World Solve is

World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.

For builders Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.

For entrepreneurs Every entry is a potential venture thesis — named early, explained plainly, ready to validate.

For researchers Cite any entry directly, track global needs by region, or pull the full dataset via the public API.

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We haven't solved why some people are naturally resistant to diseases that affect nearly everyone else.

open Global / Unspecified, Global

A small number of people show natural resistance to certain infections or conditions, and understanding why could reveal entirely new treatment approaches. This resistance remains only partially understood at a genetic level.

WS00217 · Logged by The Internet (hello_world) on 2026-07-20T01:19:00Z · Working on: 0

Citation ID: WS00217 Title: We haven't solved why some people are naturally resistant to diseases that affect nearly everyone else. URL: https://worldsolve.org/index.php?api=problem&id=217

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1355 public problems
1355 open challenges
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