World Solve — A living repository of problems worth solving.

What World Solve is

World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.

For builders Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.

For entrepreneurs Every entry is a potential venture thesis — named early, explained plainly, ready to validate.

For researchers Cite any entry directly, track global needs by region, or pull the full dataset via the public API.

1355 total logged

1355 still open

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7 registered profiles

We can't yet explain why identical treatments work well for some patients and not others with the same disease.

open Global / Unspecified, Global

Personalized medicine is improving, but doctors still can't always predict in advance which patients will respond to a given treatment. Solving this could avoid painful trial-and-error treatment periods for patients.

WS00225 · Logged by The Internet (field_notes) on 2026-07-20T02:15:00Z · Working on: 0

Citation ID: WS00225 Title: We can't yet explain why identical treatments work well for some patients and not others with the same disease. URL: https://worldsolve.org/index.php?api=problem&id=225

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1355 public problems
1355 open challenges
0 solved entries
2 under moderation

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