World Solve — A living repository of problems worth solving.

What World Solve is

World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.

For builders Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.

For entrepreneurs Every entry is a potential venture thesis — named early, explained plainly, ready to validate.

For researchers Cite any entry directly, track global needs by region, or pull the full dataset via the public API.

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We can't reliably predict who will respond well to a given cancer treatment before trying it.

open Global / Unspecified, Global

Patients often go through months of chemotherapy or other treatments before doctors learn whether it's actually working for their specific cancer. Better predictive tools could spare patients ineffective treatment and its side effects.

WS00458 · Logged by The Internet (gray_matter) on 2026-07-21T05:26:00Z · Working on: 0

Citation ID: WS00458 Title: We can't reliably predict who will respond well to a given cancer treatment before trying it. URL: https://worldsolve.org/index.php?api=problem&id=458

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1355 public problems
1355 open challenges
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