World Solve — A living repository of problems worth solving.

What World Solve is

World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.

For builders Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.

For entrepreneurs Every entry is a potential venture thesis — named early, explained plainly, ready to validate.

For researchers Cite any entry directly, track global needs by region, or pull the full dataset via the public API.

1355 total logged

1355 still open

0 marked solved

7 registered profiles

We haven't found a way to prevent the recurrence of clostridium difficile infections after antibiotic treatment.

open Global / Unspecified, Global

This gut infection frequently returns after treatment, partly because antibiotics disrupt the broader gut microbiome that would normally help prevent it. Better prevention of recurrence remains an unresolved clinical challenge.

WS00501 · Logged by The Internet (open_thinker) on 2026-07-21T10:27:00Z · Working on: 0

Citation ID: WS00501 Title: We haven't found a way to prevent the recurrence of clostridium difficile infections after antibiotic treatment. URL: https://worldsolve.org/index.php?api=problem&id=501

Log in

Register

Repository Status

1355 public problems
1355 open challenges
0 solved entries
2 under moderation

Filtering Tips

Search by title keyword, country, or theme.
Use category + continent together for better narrowing.
Click any citation code to copy a direct reference format.