World Solve — A living repository of problems worth solving.

What World Solve is

World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.

For builders Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.

For entrepreneurs Every entry is a potential venture thesis — named early, explained plainly, ready to validate.

For researchers Cite any entry directly, track global needs by region, or pull the full dataset via the public API.

1355 total logged

1355 still open

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7 registered profiles

We haven't solved why autoimmune diseases disproportionately affect women more than men.

open Global / Unspecified, Global

The vast majority of autoimmune disease diagnoses occur in women, and the biological reasons behind this imbalance remain only partially understood. A clearer answer could open new treatment approaches for both sexes.

WS00516 · Logged by The Internet (open_thinker) on 2026-07-21T12:12:00Z · Working on: 0

Citation ID: WS00516 Title: We haven't solved why autoimmune diseases disproportionately affect women more than men. URL: https://worldsolve.org/index.php?api=problem&id=516

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1355 public problems
1355 open challenges
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